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Laatste wijziging: 24 January 2022
Metabolomic and cellular alterations induced by cardiac resynchronization therapy
Principal Investigator: Prof.dr.Wilfried Mullens, Researcher: Pieter Martens
Cardiac resynchronization therapy (CRT) is one of the most effective treatments for heart failure with a reduced pump function (systolic heart failure). It is the only treatment for systolic heart failure, gives both acute symptomatic and hemodynamic improvement and also improves the long-term prognosis. The exact effects of CRT are mainly obtained via physiological studies in animal models and in patients. These studies show that CRT can result in the recovery of the right and left ventricular contractility pattern, if this were not correctly organized at the start. Unfortunately, in clinical practice, up to 30 percent of the patients with a visual disorganized contraction pattern will not respond to CRT. The patients that respond will undergo a favorable macroscopic change of the heart muscle. These observations suggest that also cellular factors play a role in the success of CRTin addition to re-organization of the contraction pattern.
The purpose of this study is to examine the beneficial effect of CRT at the cellular level.