Influence of revalidation/training therapy on cardiometabolic risk factors associated with multiple sclerosis

Principal Investigator: Prof. Dr. Bert Op't Eijnde, Researcher: Dr. ir. Inez Wens; Charly Keytsman

The purpose of this study is:

1. To investigate whether patients with multiple sclerosis (MS) have an increased cardio metabolic risk (hypertension, different body composition, disturbed heart/autonomic function, inflammation, disturbed lipid metabolism, impaired glucose tolerance ..) compared to healthy subjects.
2. To investigate the effect of exercise on these secondary health problems in MS.
3. To investigate the underlying mechanisms of impaired glucose tolerance and insulin sensitivity in this population by using muscle biopsies.
4. To examine whether individuals who participated in this study would benefit from following a rehabilitation program in their home environment, in order to reduce cardio metabolic risk factors in the future.

Publications

• Keytsman C, Hansen D, Wens I, O Eijnde B. Impact of high-intensity concurrent training on cardiovascular risk factors in persons with multiple sclerosis - pilot study. Disabil Rehabil. 2017:1-6.
   
• Keytsman C, Eijnde BO, Hansen D, Verboven K, Wens I. Elevated cardiovascular risk factors in multiple sclerosis. Mult Scler Relat Disord. 2017;17:220-223.