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KLIMOP study

Laatste wijziging: 24 januari 2022

The elderly and cancer


Principal Investigator: Prof. Dr. Frank Buntinx, Researcher: Laura Deckx


Cancer is mainly a disease of older patients. In older cancer patients, additional endpoints such as quality of survival, daily functioning and cognition might be considered equally relevant as overall or disease free survival. However, these factors have been understudied in clinical trials. Therefore, this study will focus on the impact of cancer, ageing and their interaction on the wellbeing of older cancer patients.


This study is an observational cohort study. We aim to recruit 720 cancer patients above 70 years with a new diagnosis of breast, prostate, lung or gastrointestinal cancer and two control groups: one control group of 720 patients above 70 years without a previous diagnosis of cancer and one control group of 720 cancer patients between 50 – 69 years newly diagnosed with breast, prostate, lung or gastrointestinal cancer. Data collection will take place at inclusion, after six months, after one year and every subsequent year until death or end of the study. Data will be collected through personal interviews (consisting of socio-demographic information, general health information, a comprehensive geriatric assessment, quality of life, health locus of control and a loneliness scale), a hand-grip test, assessment of medical records, two buccal swabs and a blood sample from cancer patients (at baseline). As an annex study, caregivers of the participants will be recruited as well. Data collection for caregivers will consist of a self-administered questionnaire examining depression, coping and burden.


This extensive data collection will increase insight on how wellbeing of older cancer patients is affected by cancer (diagnosis and treatment), ageing and their interaction. Results may provide new insights which might contribute to the improvement of care for older cancer patients.