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IMMMS study

Laatste wijziging: 24 januari 2022

Study on the role of the humoral immune response in multiple sclerosis and the effect of immunomodulating therapy

 

Principal Investigator: Prof. Dr. Veerle Somers

 

Multiple sclerosis (MS) is a complex inflammatory disorder of the central nervous system (CNV) characterized by demyelination and damage to nerve axons. Recent studies have shown that the humoral immune response, namely B-cells and antibodies produced by B-cells, play an important role in the pathogenesis of MS. The goal of this project is to get more insight in the role of the humoral immune response in MS and the effect of immunomodulating therapy. The biological properties of a new panel of candidate auto-antigens and their relevance in the pathological process of MS will be studied. Furthermore, the effect of immunomodulating therapy on the different B-cell characteristics will be investigated.